Ivermectin

[mike]

There is no such thing as a flu vaccine “booster”.
You get it once per season and each season it’s a new, different vaccine.

Most other vaccines never require boosters. The only one they does is pertussis.

Tetanus.

Nope

Conclusions

Review of >11 billion person-years of incidence data revealed no benefit associated with performing adult booster vaccinations against tetanus or diphtheria. Similar to other vaccines, this analysis supports the WHO position on adult booster vaccination and, if approved by governing health authorities, this may allow more countries to focus healthcare resources on vulnerable and undervaccinated populations.

I wasn't saying anything about the the benefits of tetanus boosters, only pointing out that they actually do them.

[Ken]

One thing I know ivermectin is good for is lice treatment. We had lice problems with two of our daughters a few years back, and nothing we tried worked. Finally our doctor prescribed Sklice, a topical medicated lotion. It cost a couple of hundred dollars for a single dose. We split it between the two girls and it worked. We since learned that the active ingredient is ivermectin, and that you can mix ivermectin (which you can buy at a pet supply store) into shampoo at the right ratio for the same effect. You can bet that's what we'll do if it ever happens again.

B-b-but that’s horse dewormer! You aren’t a horse!

Now you're just being a neigh-sayer.

[Josh]

Tetanus.

Nope

Conclusions

Review of >11 billion person-years of incidence data revealed no benefit associated with performing adult booster vaccinations against tetanus or diphtheria. Similar to other vaccines, this analysis supports the WHO position on adult booster vaccination and, if approved by governing health authorities, this may allow more countries to focus healthcare resources on vulnerable and undervaccinated populations.

I wasn't saying anything about the the benefits of tetanus boosters, only pointing out that they actually do them.

Except most of the world doesn’t do them, it’s just a U.S. things.

[Bootstrap]

One thing I know ivermectin is good for is lice treatment. We had lice problems with two of our daughters a few years back, and nothing we tried worked. Finally our doctor prescribed Sklice, a topical medicated lotion. It cost a couple of hundred dollars for a single dose. We split it between the two girls and it worked. We since learned that the active ingredient is ivermectin, and that you can mix ivermectin (which you can buy at a pet supply store) into shampoo at the right ratio for the same effect. You can bet that's what we'll do if it ever happens again.

B-b-but that’s horse dewormer! You aren’t a horse!

I'm learning new things about Mike.

[Bootstrap]

Looks like poison control centers are getting calls from people overdosing on Ivermectin.

While sometimes given to humans in small doses for head lice, scabies and other parasites, ivermectin is more commonly used in animals. Physicians are raising alarms about a growing number of people getting the drug from livestock supply centers, where it can come in highly concentrated paste or liquid forms.

Calls to poison control centers about ivermectin exposures have risen dramatically, jumping fivefold over their baseline in July, according to C.D.C. researchers, who cited data from the American Association of Poison Control Centers. Mississippi’s health department said earlier this month that 70 percent of recent calls to the state poison control center had come from people who ingested ivermectin from livestock supply stores.

Dr. Shawn Varney, a toxicologist and medical director for the South Texas Poison Center, said that in 2019 his center received 191 calls about exposure to ivermectin; so far this year the center has received 260 calls and is on pace to reach 390 by the end of the year. The vast majority of the recent calls came from people who took a veterinary product in an attempt to treat or prevent Covid-19.

“Everyone wants some cure for Covid because it’s such a devastating illness,” Dr. Varney said. “I plead with people to stop using ivermectin and get the vaccine because it’s the best protection we have at this point. Everything else is risk after risk.”

Dr. Varney said people calling the poison control center after taking ivermectin sometimes reported nausea, muscle pain and diarrhea. He noted that there have been ivermectin overdose deaths in the past, though he did not know of any specifically associated with Covid-19.

[Josh]

Except there haven’t been any actual overdoses.

In any case, what’s wrong with patients working with their doctors to follow the FLCCC protocol for ivermectin?

[RZehr]

Ivermectin was tested on HEK-293. For whatever it’s worth.

[Soloist]

Ivermectin was tested on HEK-293. For whatever it’s worth.

https://www.ncbi.nlm.nih.gov/pmc/articl ... throughout

Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil

https://medicalxpress.com/news/2020-10- ... dical.html

The big advantage of these cells, which were developed in the early 1970s, is that they now represent a "gold standard" in the pharmaceutical industry.

The timing is close, its unclear if it was tested on HEK293 when it started being used for humans or not. I'm not specifically sure when HEK293 started being used as the "gold standard" of testing. Based on my research, anything before 1980 is generally safe but after 1980 things get a little dicey.
I could likely find out for sure, but all the studies I've seen so far using HEK293 have been in 2000 and later.

[Ken]

Ivermectin was tested on HEK-293. For whatever it’s worth.

https://www.ncbi.nlm.nih.gov/pmc/articl ... throughout

Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil

https://medicalxpress.com/news/2020-10- ... dical.html

The big advantage of these cells, which were developed in the early 1970s, is that they now represent a "gold standard" in the pharmaceutical industry.

The timing is close, its unclear if it was tested on HEK293 when it started being used for humans or not. I'm not specifically sure when HEK293 started being used as the "gold standard" of testing. Based on my research, anything before 1980 is generally safe but after 1980 things get a little dicey.
I could likely find out for sure, but all the studies I've seen so far using HEK293 have been in 2000 and later.

You are assuming that pharmaceutical companies stop testing once a drug is developed. That is not the case at all. They continue to test and develop their products, especially if they exploring different dosages or alternate usages.

[Soloist]

You are assuming that pharmaceutical companies stop testing once a drug is developed. That is not the case at all. They continue to test and develop their products, especially if they exploring different dosages or alternate usages.

yeah and I'm already the minority on caring to take a stand on 1980. Your point? anyone is inconsistent on something unless they have no stance at all.

Ivermectin was approved in 1996 without the use of fetal cell testing. https://www.accessdata.fda.gov/drugsatf ... 0742ap.pdf

Pretty long read though.

That being said, I have no stance on ivermectin use. I am not reading up on the current research on using it with Covid 19 and would be somewhat concerned about people overdosing.